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A simple, rapid and precise spectrophotometric method has been developed for determining the enhancement in the aqueous solubility Dextromethorphan. Method is based on the absorbance. Dextromethorphan maximum is found at 278nm with hydrotrope dextromethorphan in double distilled water as solvent. The linearity was obtained in the concentration range of 10-120μg/ml with coefficient of correlation 0.9993.The % RSD in case of intra-day and inter day was found to be 0.8182 and 0.9438 respectively. The value of LOD and LOQ was found to be 3.76 and 1.141 respectively. The method is found to be accurate, precise and useful in quality control of API Drug and also to enhance the aqueous solubility of Dextromethorphan.

Keywords

Dextromethorphan, Hydrotropic Study, Enhancement of Solubility, Method Development and Validation

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Chemical Analysis Case Study of Underground Water in Hapur (West)

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Authors

Shiv Kumar Gupta ¹, Anuradha Singh ¹, Babita Kumar ¹, Bharti Sharma ¹

Affiliations
1 Sanskar College of Pharmacy and Research, Opp. Jindal Pipes Ltd., NH-24, Ghaziabad (U.P.) 201302, IN

Source

Asian Journal of Pharmaceutical Analysis, Vol 7, No 2 (2017), Pagination: 113-116

Abstract

Underground water contamination is a kind of water pollution or water destruction, in which various contaminants unify together to degrade quality and nature of water. Present scenario most probably support the water contamination by the humans and up to less extent by the natural disasters. The major ions which are responsible to maintain the quality of ground water are carbonate (CO₃ ^2-) and bicarbonate (HCO₃ ^-), Chloride (Cl), Sulphate (SO₄ ^--), Nitrate (NO₃ ^--), Phosphate (PO₄ ^3-), and Fluoride (F^-). The above ions are present in the form of anions. These anions are in general maintain by the cations as Ca⁺⁺,Cu⁺⁺, Mg⁺⁺, Na⁺, and K⁺. Among the above briefed ions Ca⁺⁺ and Mg++ are the ones which are responsible for the hardness of the water. These are found abundantly in the area, where manufacturing of chalk and limestone works take place. Water's hardness is determined by the concentration of multivalent cations in the water. This hard water if consumed by animals or humans lead to the terrific pathological conditions. Three water samples are collected from different locations of Pilkhuwa, District Hapur near to the location of the industry with limestone works, during summer. The ionic concentrations are expressed in mg/L.

Keywords

Ground Water Quality, Total Alkalinity, Total Hardness, Electrical Conductivity, TDS.

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